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Cadaveric dissection was completed on a 62-year-old female with acute myeloid leukemia (AML) and pancytopenia. The liver and spleen were enlarged; samples taken for histological processing and staining revealed infiltration of numerous abnormal leukemic cells. Due to the aggressive nature of AML and high risk of relapse, post-remission therapies (chemotherapy or bone marrow transplantation) are used to eliminate residual malignant cells. However, since these therapies may not be viable options for older patients, our discussion highlights alternative therapies targeting isocitrate dehydrogenase (IDH) mutations, commonly seen in AML, and their use in older adults to prevent relapse after initial induction therapy.
