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With an increasing number of women living past menopause, there is a need for research regarding the management of menopausal syndrome. Particularly, there is a need for research regarding the treatment of pain in postmenopausal women. The case described in this report follows a 52-year-old caucasian female who initially presented on February 7th, 2023 with one month of right sided sacroiliac joint pain. An extensive workup did not reveal a clear etiology of pain. Between her initial visit on day 0 and her most recent follow-up on day 435, she was treated with osteopathic manipulative treatment (OMT) on four occasions for various lumbar, sacral, and pelvic somatic dysfunctions. In addition to OMT, the patient was treated with stretches, tizanidine, naproxen, venlafaxine, a right hip injection, and estradiol. Notably, the patient experienced complete pain relief within one week of starting estrogen replacement therapy. This case is unique to existing literature and suggests that estrogen replacement therapy may have a role in sacroiliac pain relief in postmenopausal women.
