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Using Harnett County, NC, as the site of a hypothetical Malaria outbreak, a series of emergency management recommendations are proposed to mitigate and respond to the emerging public health emergency. Malaria is a mosquito-borne, infectious disease, found mostly in Sub-Saharan Africa and South America but is occasionally found in the United States. Supposing an outbreak was to occur locally, it would necessitate exploring local, state and federal resources, available for a successful cross-jurisdictional response. This paper approaches a hypothetical public health emergency using a multijurisdictional-intergovernmental approach.