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This project tested a hypothesis for a novel cause of bipolar disorder involving changes in levels of brain cholesterol. Mice were treated daily for 7 days with a vehicle (as a control) or a combination of 2 drugs at two different doses. These treatments were hypothesized to reduce brain cholesterol. At the end of the treatment, mice were tested for signs of depression using the spontaneous activity test, change in body weight and the forced swim test. Final results indicated that the only significant effect of either treatment with either dose was that drug-treated mice gained less weight than controls.
