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For centuries, plants have played a vital role in medicinal practices. Flavonoids, polyphenols, and anthocyanins found in plants provide important antioxidant benefits. Aristotelia chilensis (Maqui) and Berberis microphylla (Calafate) are a tree and an evergreen shrub native to the temperate rainforests of Chile and southern Argentina and are both recognized for their antioxidant-rich berries. Neuroblastoma (NB) is a tumor of the peripheral nervous system and is the most common cancer and extracranial solid tumor in infants. N18TG2 is an established mouse NB cell line. We hypothesize that Maqui leaves extract and Calafate berry extracts exert anti-proliferative effects on N18TG2 cells.
