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A tablet that effectively combines immediate and modified-release properties will be developed by compressing the tablet with a hollow core, applying an enteric coating, and filling the core with concentrated drug granules. Acetaminophen will be used as a model drug. The thickness, hardness, friability, and disintegration tests will be performed on the tablets. Key manufacturing parameters, including formulation matrix, choice of excipients, and coating will be optimized to achieve the desired release profile. A design of experiment (DoE) approach will be implemented via to systematically evaluate and refine these parameters, ensuring the effective release and stability of the formulation.
