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Thyroid nodules are prevalent in the general population and require a systematic approach of evaluation and management. This case focuses on the cadaveric dissection of a 91-year-old female revealing three benign thyroid nodules. Risk factors for the development of thyroid nodules include various lifestyle and environmental factors. Assessment begins with history and physical examination, lab studies, and high-resolution ultrasound. Select individuals with suspected malignancy may undergo additional evaluation via fine-needle aspiration biopsy. Management strategies balance between invasive and non-invasive options. Understanding the etiology, susceptibility, and appropriate interventions ensures optimized care for patients with thyroid nodules.